TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury: ROLE OF MITOCHONDRIA

Cardiac TRPM2 channels were activated by intracellular adenosine diphosphate-ribose and blocked by flufenamic acid. In adult cardiac myocytes the ratio of G(Ca) to G(Na) of TRPM2 channels was 0.56 ± 0.02. To explore the cellular mechanisms by which TRPM2 channels protect against cardiac ischemia/rep...

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Autori principali: Miller, Barbara A., Hoffman, Nicholas E., Merali, Salim, Zhang, Xue-Qian, Wang, JuFang, Rajan, Sudarsan, Shanmughapriya, Santhanam, Gao, Erhe, Barrero, Carlos A., Mallilankaraman, Karthik, Song, Jianliang, Gu, Tongda, Hirschler-Laszkiewicz, Iwona, Koch, Walter J., Feldman, Arthur M., Madesh, Muniswamy, Cheung, Joseph Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953274/
https://ncbi.nlm.nih.gov/pubmed/24492610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533851
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