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Dissociated Presenilin-1 and TACE Processing of ErbB4 in Lung Alveolar Type II Cell Differentiation

Neuregulin (NRG) stimulation of ErbB4 signaling is important for type II cell surfactant synthesis. ErbB4 may mediate gene expression via a non-canonical pathway involving enzymatic cleavage releasing its intracellular domain (4ICD) for nuclear trafficking and gene regulation. The accepted model for...

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Hlavní autoři: Fiaturi, Najla, Ritzkat, Anika, Dammann, Christiane E. L., Castellot, John J., Nielsen, Heber C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953239/
https://ncbi.nlm.nih.gov/pubmed/24462774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2014.01.015
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