Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

Phosphotyrosine peptide binding to Grb2 induces tryptophan fluorescence changes in the Src homology 2 (SH2) domain. Affinities are in the nanomolar range, the Shc peptide having the highest affinity, followed by peptides mimicking Grb2 binding sites on EGF and HGF receptors, the putative sites on in...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	EMBO J
Autori principali:	Cussac, D, Frech, M, Chardin, P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395321/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7521298/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06717.x
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!