Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

Phosphotyrosine peptide binding to Grb2 induces tryptophan fluorescence changes in the Src homology 2 (SH2) domain. Affinities are in the nanomolar range, the Shc peptide having the highest affinity, followed by peptides mimicking Grb2 binding sites on EGF and HGF receptors, the putative sites on in...

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Bibliographic Details

Published in:	EMBO J
Main Authors:	Cussac, D, Frech, M, Chardin, P
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 1994
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395321/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7521298/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06717.x
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