β1-Adrenergic Receptor and Sphingosine-1-Phosphate Receptor 1 Reciprocal Down-Regulation Influences Cardiac Hypertrophic Response and Progression Toward Heart Failure: Protective Role of S1PR1 Cardiac Gene Therapy

BACKGROUND: The Sphingosine-1-phosphate receptor 1 (S1PR1) and β1-adrenergic receptor (β1AR) are G protein-coupled receptors (GPCRs) expressed in the heart. These two GPCRs have opposing actions on adenylyl cyclase due to differential G protein-coupling. Importantly, both of these receptors can be r...

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Detaylı Bibliyografya
Asıl Yazarlar: Cannavo, Alessandro, Rengo, Giuseppe, Liccardo, Daniela, Pagano, Gennaro, Zincarelli, Carmela, De Angelis, Maria Carmen, Puglia, Roberto, Di Pietro, Elisa, Rabinowitz, Joseph E., Barone, Maria Vittoria, Cirillo, Plinio, Trimarco, Bruno, Palmer, Timothy M., Ferrara, Nicola, Koch, Walter J., Leosco, Dario, Rapacciuolo, Antonio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952877/
https://ncbi.nlm.nih.gov/pubmed/23969695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.002659
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