β1-Adrenergic Receptor and Sphingosine-1-Phosphate Receptor 1 Reciprocal Down-Regulation Influences Cardiac Hypertrophic Response and Progression Toward Heart Failure: Protective Role of S1PR1 Cardiac Gene Therapy

BACKGROUND: The Sphingosine-1-phosphate receptor 1 (S1PR1) and β1-adrenergic receptor (β1AR) are G protein-coupled receptors (GPCRs) expressed in the heart. These two GPCRs have opposing actions on adenylyl cyclase due to differential G protein-coupling. Importantly, both of these receptors can be r...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Cannavo, Alessandro, Rengo, Giuseppe, Liccardo, Daniela, Pagano, Gennaro, Zincarelli, Carmela, De Angelis, Maria Carmen, Puglia, Roberto, Di Pietro, Elisa, Rabinowitz, Joseph E., Barone, Maria Vittoria, Cirillo, Plinio, Trimarco, Bruno, Palmer, Timothy M., Ferrara, Nicola, Koch, Walter J., Leosco, Dario, Rapacciuolo, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952877/
https://ncbi.nlm.nih.gov/pubmed/23969695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.002659
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados