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Unexpectedly high affinity of a novel histamine H3 receptor antagonist, GSK239512, in vivo in human brain, determined using PET

BACKGROUND AND PURPOSE: This study aimed to investigate the relationship between the plasma concentration (PK) of the novel histamine H(3) receptor antagonist, GSK239512, and the brain occupancy of H(3) receptors (RO) in healthy human volunteers. EXPERIMENTAL APPROACH: PET scans were obtained after...

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מידע ביבליוגרפי
Main Authors: Ashworth, S, Berges, A, Rabiner, E A, Wilson, A A, Comley, R A, Lai, R Y K, Boardley, R, Searle, G, Gunn, R N, Laruelle, M, Cunningham, V J
פורמט: Artigo
שפה:Inglês
יצא לאור: Blackwell Publishing Ltd 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952801/
https://ncbi.nlm.nih.gov/pubmed/24670146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12505
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