Unexpectedly high affinity of a novel histamine H3 receptor antagonist, GSK239512, in vivo in human brain, determined using PET

BACKGROUND AND PURPOSE: This study aimed to investigate the relationship between the plasma concentration (PK) of the novel histamine H(3) receptor antagonist, GSK239512, and the brain occupancy of H(3) receptors (RO) in healthy human volunteers. EXPERIMENTAL APPROACH: PET scans were obtained after...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Ashworth, S, Berges, A, Rabiner, E A, Wilson, A A, Comley, R A, Lai, R Y K, Boardley, R, Searle, G, Gunn, R N, Laruelle, M, Cunningham, V J
פורמט: Artigo
שפה:Inglês
יצא לאור: Blackwell Publishing Ltd 2014
נושאים:
Research Papers
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952801/
https://ncbi.nlm.nih.gov/pubmed/24670146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12505
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים