Unexpectedly high affinity of a novel histamine H3 receptor antagonist, GSK239512, in vivo in human brain, determined using PET

BACKGROUND AND PURPOSE: This study aimed to investigate the relationship between the plasma concentration (PK) of the novel histamine H(3) receptor antagonist, GSK239512, and the brain occupancy of H(3) receptors (RO) in healthy human volunteers. EXPERIMENTAL APPROACH: PET scans were obtained after...

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Detalhes bibliográficos
Main Authors: Ashworth, S, Berges, A, Rabiner, E A, Wilson, A A, Comley, R A, Lai, R Y K, Boardley, R, Searle, G, Gunn, R N, Laruelle, M, Cunningham, V J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952801/
https://ncbi.nlm.nih.gov/pubmed/24670146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12505
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