Changes in Malaria Parasite Drug Resistance in an Endemic Population Over a 25-Year Period With Resulting Genomic Evidence of Selection

Background. Analysis of genome-wide polymorphism in many organisms has potential to identify genes under recent selection. However, data on historical allele frequency changes are rarely available for direct confirmation. Methods. We genotyped single nucleotide polymorphisms (SNPs) in 4 Plasmodium f...

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Main Authors: Nwakanma, Davis C., Duffy, Craig W., Amambua-Ngwa, Alfred, Oriero, Eniyou C., Bojang, Kalifa A., Pinder, Margaret, Drakeley, Chris J., Sutherland, Colin J., Milligan, Paul J., MacInnis, Bronwyn, Kwiatkowski, Dominic P., Clark, Taane G., Greenwood, Brian M., Conway, David J.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
Major Articles and Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952670/
https://ncbi.nlm.nih.gov/pubmed/24265439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit618
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