Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

TET2 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies including MDS, CMML, MPN, and AML. However, little is known regarding the biological function of TET2 and its role in the pathogenesis of myeloid malignancies. To study the function of TET2 in vivo, we generated...

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Detalhes bibliográficos
Main Authors: Li, Zhe, Cai, Xiaoqiang, Cai, Chen-Leng, Wang, Jiapeng, Zhang, Wenyong, Petersen, Bruce E., Yang, Feng-Chun, Xu, Mingjiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952630/
https://ncbi.nlm.nih.gov/pubmed/21803851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-325241
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