Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

TET2 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies including MDS, CMML, MPN, and AML. However, little is known regarding the biological function of TET2 and its role in the pathogenesis of myeloid malignancies. To study the function of TET2 in vivo, we generated...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Li, Zhe, Cai, Xiaoqiang, Cai, Chen-Leng, Wang, Jiapeng, Zhang, Wenyong, Petersen, Bruce E., Yang, Feng-Chun, Xu, Mingjiang
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2011
Sujets:
Plenary Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952630/
https://ncbi.nlm.nih.gov/pubmed/21803851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-325241
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