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Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
TET2 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies including MDS, CMML, MPN, and AML. However, little is known regarding the biological function of TET2 and its role in the pathogenesis of myeloid malignancies. To study the function of TET2 in vivo, we generated...
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Auteurs principaux: | , , , , , , , |
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Format: | Artigo |
Langue: | Inglês |
Publié: |
American Society of Hematology
2011
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3952630/ https://ncbi.nlm.nih.gov/pubmed/21803851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-325241 |
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