Isolation of high affinity human antibodies directly from large synthetic repertoires.

Antibody fragments of moderate affinity (approximately microM) can be isolated from repertoires of approximately 10(8) immunoglobulin genes by phage display and rounds of selection with antigen, and the affinities improved by further rounds of mutation and selection. Here, as an alternative strategy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Griffiths, A D, Williams, S C, Hartley, O, Tomlinson, I M, Waterhouse, P, Crosby, W L, Kontermann, R E, Jones, P T, Low, N M, Allison, T J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1994
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC395221/
https://ncbi.nlm.nih.gov/pubmed/8045255
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