Isolation of high affinity human antibodies directly from large synthetic repertoires.

Antibody fragments of moderate affinity (approximately microM) can be isolated from repertoires of approximately 10(8) immunoglobulin genes by phage display and rounds of selection with antigen, and the affinities improved by further rounds of mutation and selection. Here, as an alternative strategy...

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Bibliografiske detaljer
Main Authors: Griffiths, A D, Williams, S C, Hartley, O, Tomlinson, I M, Waterhouse, P, Crosby, W L, Kontermann, R E, Jones, P T, Low, N M, Allison, T J
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC395221/
https://ncbi.nlm.nih.gov/pubmed/8045255
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