A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage.

It has been suggested that recombination and shuffling between exons has been a key feature in the evolution of proteins. We propose that this strategy could also be used for the artificial evolution of proteins in bacteria. As a first step, we illustrate the use of a self-splicing group I intron wi...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Fisch, I, Kontermann, R E, Finnern, R, Hartley, O, Soler-Gonzalez, A S, Griffiths, A D, Winter, G
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38821/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755549/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.15.7761
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