β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

OBJECTIVES: Pathologic fibroblast activation drives fibrosis of the skin and internal organs in patients with systemic sclerosis (SSc). β-catenin is an integral part of adherens junctions and a central component of canonical Wnt signaling. Here, the authors addressed the role of β-catenin in fibrobl...

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Hauptverfasser: Beyer, Christian, Schramm, Amelie, Akhmetshina, Alfiya, Dees, Clara, Kireva, Trayana, Gelse, Kolja, Sonnylal, Sonali, de Crombrugghe, Benoit, Taketo, Makoto Mark, Distler, Oliver, Schett, Georg, Distler, Jörg H W
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951949/
https://ncbi.nlm.nih.gov/pubmed/22328737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-200568
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