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Function, targets and evolution of Caenorhabditis elegans piRNAs

Piwi-interacting RNAs (piRNAs) are small RNAs required to maintain germline integrity and fertility but their mechanism of action is poorly understood. Here we demonstrate that C. elegans piRNAs silence transcripts in trans through imperfectly complementary sites. Target silencing is independent of...

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Bibliografische gegevens
Hoofdauteurs: Bagijn, Marloes P., Goldstein, Leonard D., Sapetschnig, Alexandra, Weick, Eva-Maria, Bouasker, Samir, Lehrbach, Nicolas J., Simard, Martin J., Miska, Eric A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951736/
https://ncbi.nlm.nih.gov/pubmed/22700655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1220952
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