Function, targets and evolution of Caenorhabditis elegans piRNAs

Piwi-interacting RNAs (piRNAs) are small RNAs required to maintain germline integrity and fertility but their mechanism of action is poorly understood. Here we demonstrate that C. elegans piRNAs silence transcripts in trans through imperfectly complementary sites. Target silencing is independent of...

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Bibliografski detalji
Glavni autori: Bagijn, Marloes P., Goldstein, Leonard D., Sapetschnig, Alexandra, Weick, Eva-Maria, Bouasker, Samir, Lehrbach, Nicolas J., Simard, Martin J., Miska, Eric A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951736/
https://ncbi.nlm.nih.gov/pubmed/22700655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1220952
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