Piwi and piRNAs Act Upstream of an Endogenous siRNA Pathway to suppress Tc3 Transposon Mobility in the Caenorhabditis elegans germline

The Piwi proteins of the Argonaute superfamily are required for normal germline development in Drosophila, zebrafish and mice, and associate with 24-30 nucleotide RNAs termed piRNAs. We identify a class of 21 nucleotide RNAs, previously named 21U-RNAs, as the piRNAs of C. elegans. Piwi and piRNA exp...

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Autores principales: Das, Partha P., Bagijn, Marloes P., Goldstein, Leonard D., Woolford, Julie R., Lehrbach, Nicolas J., Sapetschnig, Alexandra, Buhecha, Heeran R., Gilchrist, Michael J., Howe, Kevin L., Stark, Rory, Matthews, Nik, Berezikov, Eugene, Ketting, René F., Tavaré, Simon, Miska, Eric A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353317/
https://ncbi.nlm.nih.gov/pubmed/18571451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.06.003
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