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Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function
Mutations at solvent inaccessible core positions in proteins can impact function through many biophysical mechanisms including alterations to thermodynamic stability and protein dynamics. As these properties of proteins are difficult to investigate, the impacts of core mutations on protein function...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3951674/ https://ncbi.nlm.nih.gov/pubmed/24361330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.10.042 |
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