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Alanine Scan Reveals Modifiable Residues in Teixobactin
An alanine scan of Lys(10)-teixobactin reveals that a cationic residue at position 10 is not necessary for antibiotic activity and that position 3 tolerates substitution without loss of activity. An unexpected correlation between poor aqueous solubility and better antibiotic activity of the teixobac...
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| Publicado en: | Chem Commun (Camb) |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6361391/ https://ncbi.nlm.nih.gov/pubmed/28967925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc03415f |
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