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Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of its Self-association to DED/DED Interactions
Absent in melanoma 2 (AIM2) is a cytoplasmic dsDNA sensor involved in innate immunity. It uses its C-terminal HIN domain for recognizing dsDNA and its N-terminal Pyrin domain (PYD) for eliciting downstream effects through recruitment and activation of Apoptosis-associated Speck-like protein containi...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3951648/ https://ncbi.nlm.nih.gov/pubmed/24406744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.12.029 |
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