Necroptosis drives motor neuron death in models of both sporadic and familial ALS

Most cases of neurodegenerative disease are sporadic, hindering the use of genetic mouse models to analyze disease mechanisms. Focusing on the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS) we therefore devised a fully humanized co-culture model composed of human adult primary sporadi...

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Main Authors: Re, Diane B., Verche, Virginia Le, Yu, Changhao, Amoroso, Mackenzie W., Politi, Kristin A., Phani, Sudarshan, Ikiz, Burcin, Hoffmann, Lucas, Koolen, Martijn, Nagata, Tetsuya, Papadimitriou, Dimitra, Nagy, Peter, Mitsumoto, Hiroshi, Kariya, Shingo, Wichterle, Hynek, Henderson, Christopher E., Przedborski, Serge
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951532/
https://ncbi.nlm.nih.gov/pubmed/24508385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.01.011
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