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KB-R7943, a plasma membrane Na(+)/Ca(2+) exchanger inhibitor, blocks opening of the mitochondrial permeability transition pore

The isothiourea derivative, KB-R7943, inhibits the reverse-mode of the plasma membrane sodium/calcium exchanger and protects against ischemia/reperfusion injury. The mechanism through which KB-R7943 confers protection, however, remains controversial. Recently, KB-R7943 has been shown to inhibit mito...

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Bibliografske podrobnosti
Main Authors: Wiczer, Brian M., Marcu, Raluca, Hawkins, Brian J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951502/
https://ncbi.nlm.nih.gov/pubmed/24434143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.01.009
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