KB-R7943, an inhibitor of the reverse Na(+)/Ca(2+) exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I

BACKGROUND AND PURPOSE: An isothiourea derivative (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methane sulfonate (KB-R7943), a widely used inhibitor of the reverse Na(+)/Ca(2+) exchanger (NCX(rev)), was instrumental in establishing the role of NCX(rev) in glutamate-induced Ca(2+) deregulation...

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Detalhes bibliográficos
Main Authors: Brustovetsky, Tatiana, Brittain, Matthew K, Sheets, Patrick L, Cummins, Theodore R, Pinelis, Vsevolod, Brustovetsky, Nickolay
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012420/
https://ncbi.nlm.nih.gov/pubmed/20883473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01054.x
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