Negative regulation by PD-L1 during drug-specific priming of IL-22 secreting T-cells and the influence of PD-1 on effector T-cell function

Activation of PD-1 on T-cells is thought to inhibit antigen-specific T-cell priming and regulate T-cell differentiation. Thus, we sought to measure the drug-specific activation of naïve T-cells after perturbation of PD-L1/2/PD-1 binding and investigate whether PD-1 signaling influences the different...

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Détails bibliographiques
Auteurs principaux: Gibson, Andrew, Ogese, Monday, Sullivan, Andrew, Wang, Eryi, Saide, Katy, Whitaker, Paul, Peckham, Daniel, Faulkner, Lee, Park, B. Kevin, Naisbitt, Dean J.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951492/
https://ncbi.nlm.nih.gov/pubmed/24510967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302720
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