The effect of inhibitory signals on the priming of drug-hapten-specific T-cells that express distinct Vβ receptors

Drug hypersensitivity involves the activation of T-cells in an HLA allele-restricted manner. Since the majority of individuals who carry HLA risk alleles do not develop hypersensitivity, other parameters must control development of the drug-specific T-cell response. Thus, we have utilized a T-cell p...

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Veröffentlicht in:J Immunol
Hauptverfasser: Gibson, Andrew, Faulkner, Lee, Lichtenfels, Maike, Ogese, Monday, Al-Attar, Zaid, Alfirevic, Ana, Esser, Philipp R., Martin, Stefan F., Pirmohamed, Munir, Park, B. Kevin, Naisbitt, Dean J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551967/
https://ncbi.nlm.nih.gov/pubmed/28687658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1602029
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