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ABCB1 1199G>A Genetic Polymorphism (Rs2229109) Influences the Intracellular Accumulation of Tacrolimus in HEK293 and K562 Recombinant Cell Lines

OBJECTIVE: ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-glycoprotein, is an efflux protein implicated in the absorption and the distribution of various compounds, including tacrolimus and cyclosporine A. In vivo studies suggest an association between the ABCB1 1199G>A sin...

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Bibliografiske detaljer
Main Authors: Dessilly, Géraldine, Elens, Laure, Panin, Nadtha, Capron, Arnaud, Decottignies, Anabelle, Demoulin, Jean-Baptiste, Haufroid, Vincent
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951418/
https://ncbi.nlm.nih.gov/pubmed/24621983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091555
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