27-Hydroxycholesterol Promotes Cell-autonomous ER-positive Breast Cancer Growth

To date estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report that the cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice. More importantly, in ER+ breast cancer patients, 27HC content in n...

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Detalhes bibliográficos
Main Authors: Wu, Qian, Ishikawa, Tomonori, Sirianni, Rosa, Tang, Hao, McDonald, Jeffrey G., Yuhanna, Ivan S., Thompson, Bonne, Girard, Luc, Mineo, Chieko, Brekken, Rolf A., Umetani, Michihisa, Euhus, David M., Xie, Yang, Shaul, Philip W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950897/
https://ncbi.nlm.nih.gov/pubmed/24210818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.006
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