Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation

BACKGROUND: Glioblastoma multiforme (GBM), a highly invasive primary brain tumour, remains an incurable disease. Rho GTPases and their activators, guanine nucleotide exchange factors (GEFs), have central roles in GBM invasion. Anti-angiogenic therapies may stimulate GBM invasion via HGF/c-Met signal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Murray, D W, Didier, S, Chan, A, Paulino, V, Van Aelst, L, Ruggieri, R, Tran, N L, Byrne, A T, Symons, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
Schlagworte:
Molecular Diagnostics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950876/
https://ncbi.nlm.nih.gov/pubmed/24518591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.39
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