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Nucleosomes accelerate transcription factor dissociation

Transcription factors (TF) bind DNA-target sites within promoters to activate gene expression. TFs target their DNA-recognition sequences with high specificity by binding with resident times of up to hours in vitro. However, in vivo TFs can exchange on the order of seconds. The factors that regulate...

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Autors principals: Luo, Yi, North, Justin A., Rose, Sean D., Poirier, Michael G.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950707/
https://ncbi.nlm.nih.gov/pubmed/24353316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1319
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