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Nucleosomes accelerate transcription factor dissociation

Transcription factors (TF) bind DNA-target sites within promoters to activate gene expression. TFs target their DNA-recognition sequences with high specificity by binding with resident times of up to hours in vitro. However, in vivo TFs can exchange on the order of seconds. The factors that regulate...

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Detalhes bibliográficos
Main Authors: Luo, Yi, North, Justin A., Rose, Sean D., Poirier, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950707/
https://ncbi.nlm.nih.gov/pubmed/24353316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1319
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