Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo

Cryptococcosis is an infectious disease of global significance for which new therapies are needed. Repurposing previously developed drugs for new indications can expedite the translation of new therapies from bench to beside. Here, we characterized the anti-cryptococcal activity and antifungal mecha...

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Detalhes bibliográficos
Main Authors: Butts, Arielle, Koselny, Kristy, Chabrier-Roselló, Yeissa, Semighini, Camile P., Brown, Jessica C. S., Wang, Xuying, Annadurai, Sivakumar, DiDone, Louis, Tabroff, Julie, Childers, Wayne E., Abou-Gharbia, Magid, Wellington, Melanie, Cardenas, Maria E., Madhani, Hiten D., Heitman, Joseph, Krysan, Damian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950514/
https://ncbi.nlm.nih.gov/pubmed/24520056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00765-13
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