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Cryptococcus neoformans Phosphoinositide-Dependent Kinase 1 (PDK1) Ortholog Is Required for Stress Tolerance and Survival in Murine Phagocytes

Cryptococcus neoformans PKH2-01 and PKH2-02 are orthologous to mammalian PDK1 kinase genes. Although orthologs of these kinases have been extensively studied in S. cerevisiae, little is known about their function in pathogenic fungi. In this study, we show that PKH2-02 but not PKH2-01 is required fo...

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Main Authors: Chabrier-Roselló, Yeissa, Gerik, Kimberly J., Koselny, Kristy, DiDone, Louis, Lodge, Jennifer K., Krysan, Damian J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535849/
https://ncbi.nlm.nih.gov/pubmed/23087368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00235-12
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