Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid binding protein

The human APOBEC3 proteins are a family of DNA-editing enzymes that play an important role in the innate immune response and have broad activity against retroviruses and retrotransposons. APOBEC3G is a member of this family that inhibits HIV-1 replication in the absence of the viral infectivity fact...

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Detalhes bibliográficos
Main Authors: Chaurasiya, Kathy R., McCauley, Micah J., Wang, Wei, Qualley, Dominic F., Wu, Tiyun, Kitamura, Shingo, Geertsema, Hylkje, Chan, Denise S.B., Hertz, Amber, Iwatani, Yasumasa, Levin, Judith G., Musier-Forsyth, Karin, Rouzina, Ioulia, Williams, Mark C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950479/
https://ncbi.nlm.nih.gov/pubmed/24345943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1795
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