A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

As bona fide p53 transcriptional targets, miR-34 microRNAs (miRNAs) exhibit frequent alterations in many human tumor types and elicit multiple p53 downstream effects upon overexpression. Unexpectedly, miR-34 deletion alone fails to impair multiple p53-mediated tumor suppressor effects in mice, possi...

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Autori principali: Okada, Nobuhiro, Lin, Chao-Po, Ribeiro, Marcelo C., Biton, Anne, Lai, Gregory, He, Xingyue, Bu, Pengcheng, Vogel, Hannes, Jablons, David M., Keller, Andreas C., Wilkinson, J. Erby, He, Biao, Speed, Terry P., He, Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950342/
https://ncbi.nlm.nih.gov/pubmed/24532687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.233585.113
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