Hypoxia Promotes Migration and Induces CXCR4 Expression via HIF-1α Activation in Human Osteosarcoma

BACKGROUND: Cellular adaptation to a hypoxic microenvironment is essential for tumor progression and is largely mediated by HIF-1α through coordinated regulation of hypoxia-responsive genes. The chemokine SDF-1α and its unique receptor CXCR4 have been implicated in organ-specific metastases of many...

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Detalhes bibliográficos
Main Authors: Guo, Mingjun, Cai, Chengkui, Zhao, Guangyi, Qiu, Xiuchun, Zhao, Haien, Ma, Qiong, Tian, Liying, Li, Xuelian, Hu, Yunsheng, Liao, Bo, Ma, Baoan, Fan, Qingyu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949690/
https://ncbi.nlm.nih.gov/pubmed/24618817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090518
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