Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression

Maturation of high-affinity B lymphocytes is precisely controlled during the germinal center reaction. This is dependent on CD4(+)CXCR5(+) follicular helper T cells (T(FH)) and inhibited by CD4(+)CXCR5(+)Foxp3(+) follicular regulatory T cells (T(FR)). Because NFAT2 was found to be highly expressed a...

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Bibliografische gegevens
Hoofdauteurs: Vaeth, Martin, Müller, Gerd, Stauss, Dennis, Dietz, Lena, Klein-Hessling, Stefan, Serfling, Edgar, Lipp, Martin, Berberich, Ingolf, Berberich-Siebelt, Friederike
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949566/
https://ncbi.nlm.nih.gov/pubmed/24590764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130604
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