The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer.

SH2 domain proteins are important components of the signal transduction pathways activated by growth factor receptor tyrosine kinases. We have been cloning SH2 domain proteins by bacterial expression cloning using the tyrosine phosphorylated C-terminus of the epidermal growth factor receptor as a pr...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Stein, D, Wu, J, Fuqua, S A, Roonprapunt, C, Yajnik, V, D'Eustachio, P, Moskow, J J, Buchberg, A M, Osborne, C K, Margolis, B
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394949/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7907978/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06386.x
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