5-Aza-2′'-deoxycytidine inhibits retinoblastoma cell by reactivating epigenetically silenced RASSF1A gene

AIM: To investigate the effect of 5-Aza-2′-deoxycytidine (5-Aza-CdR), a DNA methyltransferase (DNMT) inhibitor, on the growth and survival of the Chinese retinoblastoma (RB) cell line HXO-RB(44). METHODS: The DNA methylation status of the Ras association domain family (RASSF1A) promoter in the prese...

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Autors principals: Liu, Ru, Zhang, Xiao-Huan, Zhang, Kun, Li, Wei, Wang, Wen-Jun, Luo, Di-Xian, Gao, Ling
Format: Artigo
Idioma:Inglês
Publicat: International Journal of Ophthalmology Press 2014
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949458/
https://ncbi.nlm.nih.gov/pubmed/24634863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3980/j.issn.2222-3959.2014.01.09
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