Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence.

Src homology 3 (SH3) domains are found in numerous cytoplasmic proteins involved in intracellular signal transduction. We used 2-D 1H NMR to determine the structure of the SH3 domain of the guanosine triphosphatase-activating protein (GAP), an essential component of the Ras signaling pathway. The st...

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Bibliografiske detaljer
Main Authors: Yang, Y S, Garbay, C, Duchesne, M, Cornille, F, Jullian, N, Fromage, N, Tocque, B, Roques, B P
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC394941/
https://ncbi.nlm.nih.gov/pubmed/8137811
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