Aggregatibacter actinomycetemcomitans Leukotoxin Utilizes a Cholesterol Recognition/Amino Acid Consensus Site for Membrane Association

Aggregatibacter actinomycetemcomitans produces a repeats-in-toxin (RTX) leukotoxin (LtxA) that selectively kills human immune cells. Binding of LtxA to its β(2) integrin receptor (lymphocyte function-associated antigen-1 (LFA-1)) results in the clustering of the toxin·receptor complex in lipid rafts...

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Autors principals: Brown, Angela C., Balashova, Nataliya V., Epand, Richard M., Epand, Raquel F., Bragin, Alvina, Kachlany, Scott C., Walters, Michael J., Du, Yurong, Boesze-Battaglia, Kathleen, Lally, Edward T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Membrane Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949334/
https://ncbi.nlm.nih.gov/pubmed/23792963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.486654
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