Insights into the Conformation of Aminofluorene-Deoxyguanine Adduct in a DNA Polymerase Active Site

The active site conformation of the mutagenic fluoroaminofluorene-deoxyguanine adduct (dG-FAF, N-(2′-deoxyguanosin-8-yl)-7-fluoro-2-aminofluorene) has been investigated in the presence of Klenow fragment of Escherichia coli DNA polymerase I (Kfexo(−)) and DNA polymerase β (pol β) using (19)F NMR, in...

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Bibliographische Detailangaben
Hauptverfasser: Vaidyanathan, Vaidyanathan G., Liang, Fengting, Beard, William A., Shock, David D., Wilson, Samuel H., Cho, Bongsup P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949331/
https://ncbi.nlm.nih.gov/pubmed/23798703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476150
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