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p53 activity is selectively licensed in the Drosophila stem cell compartment
Oncogenic stress provokes tumor suppression by p53 but the extent to which this regulatory axis is conserved remains unknown. Using a biosensor to visualize p53 action, we find that Drosophila p53 is selectively active in gonadal stem cells after exposure to stressors that destabilize the genome. Si...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3949305/ https://ncbi.nlm.nih.gov/pubmed/24618896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01530 |
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