Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart

In vitro studies suggested that glucose metabolism through the oxidative pentose phosphate pathway (oxPPP) can paradoxically feed superoxide-generating enzymes in failing hearts. We therefore tested the hypothesis that acute inhibition of the oxPPP reduces oxidative stress and enhances function and...

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Main Authors: Vimercati, Claudio, Qanud, Khaled, Mitacchione, Gianfranco, Sosnowska, Danuta, Ungvari, Zoltan, Sarnari, Roberto, Mania, Daniella, Patel, Neel, Hintze, Thomas H., Gupte, Sachin A., Stanley, William C., Recchia, Fabio A.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2014
Teme:
Energetics and Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949072/
https://ncbi.nlm.nih.gov/pubmed/24414069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00783.2013
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