Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart

In vitro studies suggested that glucose metabolism through the oxidative pentose phosphate pathway (oxPPP) can paradoxically feed superoxide-generating enzymes in failing hearts. We therefore tested the hypothesis that acute inhibition of the oxPPP reduces oxidative stress and enhances function and...

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Autors principals: Vimercati, Claudio, Qanud, Khaled, Mitacchione, Gianfranco, Sosnowska, Danuta, Ungvari, Zoltan, Sarnari, Roberto, Mania, Daniella, Patel, Neel, Hintze, Thomas H., Gupte, Sachin A., Stanley, William C., Recchia, Fabio A.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
Matèries:
Energetics and Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949072/
https://ncbi.nlm.nih.gov/pubmed/24414069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00783.2013
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