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Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart

In vitro studies suggested that glucose metabolism through the oxidative pentose phosphate pathway (oxPPP) can paradoxically feed superoxide-generating enzymes in failing hearts. We therefore tested the hypothesis that acute inhibition of the oxPPP reduces oxidative stress and enhances function and...

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Detalhes bibliográficos
Main Authors: Vimercati, Claudio, Qanud, Khaled, Mitacchione, Gianfranco, Sosnowska, Danuta, Ungvari, Zoltan, Sarnari, Roberto, Mania, Daniella, Patel, Neel, Hintze, Thomas H., Gupte, Sachin A., Stanley, William C., Recchia, Fabio A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949072/
https://ncbi.nlm.nih.gov/pubmed/24414069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00783.2013
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