Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.

To elucidate the role of the CD3 eta subunit of the T cell receptor (TCR) in thymic development, a CD3 eta -/- mouse was generated by gene targeting. Insertion of a neomycin resistance gene into exon 9 of the CD3 zeta/eta/phi locus disrupted expression of CD3 eta and CD3 phi without affecting the ex...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Koyasu, S, Hussey, R E, Clayton, L K, Lerner, A, Pedersen, R, Delany-Heiken, P, Chau, F, Reinherz, E L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394877/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8112294/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06321.x
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