Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.

To elucidate the role of the CD3 eta subunit of the T cell receptor (TCR) in thymic development, a CD3 eta -/- mouse was generated by gene targeting. Insertion of a neomycin resistance gene into exon 9 of the CD3 zeta/eta/phi locus disrupted expression of CD3 eta and CD3 phi without affecting the ex...

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Bibliografiske detaljer
Main Authors: Koyasu, S, Hussey, R E, Clayton, L K, Lerner, A, Pedersen, R, Delany-Heiken, P, Chau, F, Reinherz, E L
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC394877/
https://ncbi.nlm.nih.gov/pubmed/8112294
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