PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

Phosphatidylinositol 3-kinase (PI 3-kinase) has a regulatory 85 kDa adaptor subunit whose SH2 domains bind phosphotyrosine in specific recognition motifs, and a catalytic 110 kDa subunit. Mutagenesis of the p110 subunit, within a sequence motif common to both protein and lipid kinases, demonstrates...

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Autors principals: Dhand, R, Hiles, I, Panayotou, G, Roche, S, Fry, M J, Gout, I, Totty, N F, Truong, O, Vicendo, P, Yonezawa, K
Format: Artigo
Idioma:Inglês
Publicat: 1994
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC394841/
https://ncbi.nlm.nih.gov/pubmed/8313897
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