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A lipid-mediated conformational switch modulates the thermosensing activity of DesK

The thermosensor DesK is a multipass transmembrane histidine-kinase that allows the bacterium Bacillus subtilis to adjust the levels of unsaturated fatty acids required to optimize membrane lipid fluidity. The cytoplasmic catalytic domain of DesK behaves like a kinase at low temperature and like a p...

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Bibliografiske detaljer
Main Authors: Inda, María Eugenia, Vandenbranden, Michel, Fernández, Ariel, de Mendoza, Diego, Ruysschaert, Jean-Marie, Cybulski, Larisa Estefanía
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948243/
https://ncbi.nlm.nih.gov/pubmed/24522108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317147111
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