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Interhelical H-Bonds Modulate the Activity of a Polytopic Transmembrane Kinase

DesK is a Histidine Kinase that allows Bacillus subtilis to maintain lipid homeostasis in response to changes in the environment. It is located in the membrane, and has five transmembrane helices and a cytoplasmic catalytic domain. The transmembrane region triggers the phosphorylation of the catalyt...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Almada, Juan Cruz, Bortolotti, Ana, Ruysschaert, Jean Marie, de Mendoza, Diego, Inda, María Eugenia, Cybulski, Larisa Estefanía
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301901/
https://ncbi.nlm.nih.gov/pubmed/34201916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11070938
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