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Non-Core RAG1 Regions Promote Vβ Rearrangements and αβ T Cell Development by Overcoming Inherent Inefficiency of Vβ Recombination Signal Sequences
The RAG proteins are comprised of core endonuclease domains and non-core regions that modulate endonuclease activity. Mutation or deletion of non-core RAG regions in humans causes immunodeficiency and altered TCR repertoire, and mice expressing core but not full-length Rag1 (Rag1(C/C)) or Rag2 (Rag2...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3948170/ https://ncbi.nlm.nih.gov/pubmed/24415779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301599 |
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